Andrea Califano is the Clyde and Helen Wu Professor of Chemical and Systems Biology at Columbia University Irving Medical Center, in the departments of Systems Biology, Medicine, Biochemistry & Molecular Biophysics, and Biomedical Informatics, as well as the Founding Chair of the Department of Systems Biology.

He was originally trained as a physicist and has applied physics-based approaches, including extensive use of information theory principles, to the reverse engineering and interrogation of gene regulatory networks to systematically and efficiently identify key tumor checkpoint modules, whose aberrant activity is necessary for tumor viability. This has resulted in several clinical trials, including a very innovative N-of-1 study for precision cancer medicine.

Dr. Califano has received several awards and recognitions, including being twice recipient of the NCI Outstanding Investigator Award; Fellow of the AAAS, and of the NY Academy of Medicine and Academy of Science; and Member of the National Academy of Medicine. He is also the Co-founder of DarwinHealth Inc.