Published by JCO Precision Oncology, ASCO
“Transcriptomics in tumor and normal lung tissues identify early-stage NSCLC patients with high risk of post-surgery recurrence who may benefit from adjuvant therapies” Published by JCO Precision Oncology, ASCO

WINning together

WIN was formed on the premise that we can accomplish more together than each organization can achieve working alone. We aim to improve cancer patients’ survival and quality of life. View WIN's history and unique attributes:

WIN represents a global collaboration of cancer centers, life science and biotech organizations, pharmaceutical and technology companies and not-for-profit organizations.
The Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine was initiated in 2010 with leadership from leading cancer centers worldwide. WIN is a non-profit, non-governmental organization headquartered in Paris.

WIN was created to accelerate the pace and reduce the cost of translating novel cancer treatments to the bedside by developing and applying, through worldwide clinical trials and research projects, the most promising advances in genomic-based cancer research. WIN aims to initiate research projects each year in a global consortium guided by an independent scientific advisory board.

WIN now includes 31 institutional members. These stakeholders have come together from all parts of the world to address the challenge of increasing the efficacy of cancer diagnostics and therapeutics by understanding the genetics and biology of each individual’s tumor and accounting for genetic differences across diverse populations—from North and South America, Europe, Asia and the Middle East.

Our goal is to significantly improve outcomes for patients around the globe. We aim to increase the number of patients worldwide that have access to innovative, global clinical trials in the area of genomic-based cancer therapeutics. Global diversity and inclusion of all stakeholders is WIN’s most important and differentiating asset.
WIN is comprised of organizations representing all stakeholders in personalized cancer medicine.
WIN enables cross-sector collaborations designed to accelerate the speed and efficacy with which breakthroughs in personalized cancer medicine can be realized and brought to patients worldwide.

Our members include leading academic, pharmaceutical, life science, not-for-profit, health, patient advocacy and IT organizations.
Our members include 24 leading academic centers representing 18 countries and five continents, enabling coordinated studies with a global patient population.
The response to a genetically-targeted therapy can vary due to differences in ethnicity and environment. WIN's global studies are designed to identify and account for this variability, enhancing the speed and efficacy with which novel discoveries can be made and brought to patients around the world.

WIN prioritizes cross-sector interaction designed to enhance learning across and between continents and healthcare sectors.
WIN Symposia, held annually, brings together hundreds of leaders representing all stakeholders from around the world in a forum designed to promote the exchange of ideas and information.

Clinical trials, projects and publications

WIN members collaboratively design and carry out global studies designed to achieve breakthroughs for patients worldwide. Our distinguished Scientific Advisory Board oversees WIN studies. Current trials include:

“Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival”
WIN's article “Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival” published by NPJ Precision Oncology, a Nature Research journal.
SPRING 01 (Survival Prolongation by Rationale Innovative Genomics) proof of concept trial is the first trial exploring the tri-therapy strategy in first line of advanced/metastatic non-small cell lung cancer (NSCLC), following the historical success of this approach in AIDS and tuberculosis for which only tri-therapy demonstrated long term efficacy.
The WIN SPRING trial was conducted in the USA, France, Spain, Luxembourg and Israel in the following cancer centers: University of California - San Diego's Moores Cancer Center, Avera Cancer Center (Sioux Falls, Arizona), Institut Curie (Paris), Centre Léon Bérard (Lyon), Vall d'Hebron Institute of Oncology (Barcelona), Centre Hospitalier de Luxembourg (Luxembourg), and Chaim Sheba Medical Center (Israel).

The trial was sponsored by the WIN Consortium and funded by ARC Fondation for cancer research (France). The drugs were donated by Pfizer Inc.
Published in Nature Medicine, results of WINTHER, the first study pioneered by the WIN Consortium.
Published in Nature Medicine, results of WINTHER, the first study pioneered by the WIN Consortium.

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial - shows that RNA profiling together with DNA testing matches more patients with advanced cancer to personalized therapies than DNA profiling for tumor mutations alone.

WIN is currently planning innovative global clinical trials that represent the next generation of studies focused on lung cancer.
European funded trials WINTHER EU FP7 funded and CHEMORES EU FP6 funded established foundations for WIN future global strategy for lung cancer currently under development.

The concept underlying the new strategy is developed in the following publications:

People leadership

WIN leaders are selected for their contributions and commitment to making effective, personalized cancer medicine a reality for patients around the world. They guide WIN's strategic, operational, and scientific direction.

Organization Photo

Organization

The WIN Consortium is organized in the following groups who collectively work together to achieve WIN's common goals

Richard L. Schilsky Photo
Chairman, WIN Consortium
Richard L. Schilsky

Chairman, WIN Consortium; Professor Emeritus, University of Chicago; past President and former Executive Vice President & Chief Medical Officer (ASCO) (USA)

Josep Tabernero Photo
Vice Chairman, WIN Consortium
Josep Tabernero

Vice Chairman, WIN Consortium; Head, Medical Oncology Department, Vall d'Hebron University Hospital (HUVH); Director, Vall d'Hebron Institute of Oncology, VHIO (Spain)

Razelle Kurzrock Photo
Chief Medical Officer, Executive Committee, Equal Opportunity and Diversity Officer, WIN Consortium
Razelle Kurzrock

Chief Medical Officer, WIN Consortium; Professor of Medicine, Associate Director, Clinical Research, Linda T. and John A. Mellowes Endowed Chair of Precision Oncology (USA)

Vladimir Lazar Photo
Chief Scientific and Operating Officer, WIN Consortium
Vladimir Lazar

Chief Scientific and Operating Officer, WIN Consortium

Catherine Bresson Photo
Director, Operational Team, WIN Consortium
Catherine Bresson

Director, Operational Team, WIN Consortium


Our members

WIN members include 31 leading organizations representing all stakeholders in personalized cancer medicine covering 18 countries and 4 continents. Our shared vision is delivering the promise of effective, personalized cancer medicine to patients worldwide.


WIN Symposia

WIN Symposia, held annually, gathers leaders representing a breadth of stakeholders from around the world to learn, share, and collaborate. Visit http://www.winsymposium.org for registration and additional information.

WIN 2022 Symposium logotype

WIN 2022 Symposium

October 29, 2022 - October 30, 2022

The WIN 2022 Symposium ‘Integrating Genomics and Transcriptomics to Reshape Precision Oncology: A WINning Strategy’ took place on 29-30 October, 2022 in Barcelona, Spain.

We had an exciting line-up of prominent speakers and panel discussion and our 1st international molecular board!

For further information, please visit our dedicated symposium website https://www.winsymposium.org!

 

Partnership JIPO and WIN logotype

Partnership JIPO and WIN

December 03, 2021 - December 03, 2022

JIPO and WIN will cross-promote both organization’s activities throughout the year, including the WIN 2022 Symposium in Barcelona, Spain, October 29-30, 2022. Abstracts selected for presentation at the WIN meeting will be published in JIPO as a Conference Proceeding.

JIPO Editorial Fellow, Dr. Khalid Jazieh, will be interviewing members of WIN Leadership to highlight the collaboration and upcoming activities. Drs. Razelle Kurzrock, Vladimir Lazar, and Richard L. Schilsky will be interviewed. These interviews will be published on the JIPO YouTube channel in the coming weeks.

Dr. Vladimir Lazar, Chief Scientific and Operating Officer of WIN, has been appointed to the JIPO Editorial Board to represent WIN Leadership. Dr. Lazar plans to contribute an editorial to the Journal in 2022. Dr. Kurzrock has published four articles in JIPO in 2019 and 2020.

WIN 2019 Symposium logotype

WIN 2019 Symposium

June 23, 2019 - June 24, 2019

The 11th edition of the WIN Symposia ‘WINnovation and Global Deployment of Precision Oncology’ took place in Paris, France on 23-24 June 2019.

Highlights and further information on the event, WIN 2019 can be found on our dedicated website at https://www.winsymposium.org/


What people are saying

What people are saying
"WIN is an unique, global, translational clinical research organization with a bold vision to bring cutting edge science and technology to the cure of cancer worldwide. It is a privilege to help guide the organization as Chairman." Richard L. Schilsky, WIN Chairman
What people are saying
"Achieving much needed major clinical breakthroughs in cancer treatment requires bold thinking and action, a can do attitude and winning spirit, and close collaboration of stakeholders and contributors with diverse background and expertise. All this is epitomized by WIN." Vladimir Lazar, Chief Scientific and Operating Officer
What people are saying
Exploring Precision Oncology - Interview with Dr. Razelle Kurzrock, Chief Medical Officer and Dr. Sewanti Limaye at WIN 2022 Symposium  (To view the video, click on the arrow above for the next screen) JIPO and WIN Consortium
play

Exploring Precision Oncology - Interview with Dr. Razelle Kurzrock, Chief Medical Officer and Dr. Sewanti Limaye at WIN 2022 Symposium 
https://youtu.be/Uxicpg6Fb98
Therapeutic Advances in Medical Oncology: Comorbidity between lung cancer and COVID-19 pneumonia: role of immunoregulatory gene transcripts in high ACE2-expressing normal lung
SAGE Journals: Therapeutic Advances in Medical Oncology:
October 3, 2022

Abstract:
Background: SARS-CoV-2 (COVID-19) elicits a T-cell antigen-mediated immune response of variable efficacy. To understand this variability, we explored transcriptomic expression of angiotensin-converting enzyme 2 (ACE2, the SARS-CoV-2 receptor) and of immunoregulatory genes in normal lung tissues from patients with non-small cell lung cancer (NSCLC).

Methods:
This study used the transcriptomic and the clinical data for NSCLC patients generated during the CHEMORES study [n = 123 primary resected (early-stage) NSCLC] and the WINTHER clinical trial (n = 32 metastatic NSCLC).

Results:
We identified patient subgroups with high and low ACE2 expression (p = 1.55 × 10−19) in normal lung tissue, presumed to be at higher and lower risk, respectively, of developing severe COVID-19 should they become infected. ACE2 transcript expression in normal lung tissues (but not in tumor tissue) of patients with NSCLC was higher in individuals with more advanced disease. High-ACE2 expressors had significantly higher levels of CD8+ cytotoxic T lymphocytes and natural killer cells but with presumably impaired function by high Thymocyte Selection-Associated High Mobility Group Box Protein TOX (TOX) expression. In addition, immune checkpoint-related molecules – PD-L1, CTLA-4, PD-1, and TIGIT – are more highly expressed in normal (but not tumor) lung tissues; these molecules might dampen immune response to either viruses or cancer. Importantly, however, high inducible T-cell co-stimulator (ICOS), which can amplify immune and cytokine reactivity, significantly correlated with high ACE2 expression in univariable analysis of normal lung (but not lung tumor tissue).

Conclusions:
We report a normal lung immune-tolerant state that may explain a potential comorbidity risk between two diseases – NSCLC and susceptibility to COVID-19 pneumonia.

Further, a NSCLC patient subgroup has normal lung tissue expressing high ACE2 and high ICOS transcripts, the latter potentially promoting a hyperimmune response, and possibly leading to severe COVID-19 pulmonary compromise.

Keywords: ACE2 expression, cancer, COVID-19, normal lung, transcriptomics

View the full article here: Download pdf

Ther Adv Med Oncol
2022, Vol.14:1-15
DOI: 10.1177/
17588359221133893
Article reuse guidelines: sagepub.com/journals-permissions
Survival-predicting algorithm passes first big test in patients with lung cancer
September 20, 2022

https://www.youtube.com/watch?v=1sXMWuoZbI0
Transcriptomics in tumor and normal lung tissues identify early-stage NSCLC patients with high risk of post-surgery recurrence who may benefit from adjuvant therapies
JCO® Precision Oncology
September 15, 2022

Purpose:
The prognosis of patients with non–small-cell lung cancer (NSCLC), traditionally determined by anatomic histology and TNM staging, neglects the biological features of the tumor that may be important in
determining patient outcome and guiding therapeutic interventions. Identifying patients with NSCLC at increased risk of recurrence after curative-intent surgery remains an important unmet need so that known effective adjuvant treatments can be offered to those at highest risk of recurrence.

Read the full article by downloading here:
Download pdf