Clinical-trial -Win Consortium

SPRING Phase I trial results published: A WIN Consortium phase I study exploring avelumab, palbociclib, and axitinib in advanced non-small cell lung cancer

- Cancer Medicine, March 20, 2022

Download pdf

SPRING 01 Trial

SPRING 01 explored the safety and efficacy of the combination of a modulator of immune check point (avelumab), and two small molecule tyrosine kinase inhibitors (TKI) (axitinib and palbociclib).

During the Phase I, the tri-therapy was tested at different doses following a specific dose-escalation scheme in order to establish the safety and identify the recommended dose for the Phase II. The Phase II confirmed the safety and assessed the clinical utility of the tri-therapy approach in the treatment of advanced/metastatic NSCLC.

The study explored the clinical utility of the Simplified Interventional Mapping System (SIMS), a new tool/algorithm enabling matching of NSCLC patients with combination therapies. For this purpose tumor/metastasis and matched normal tissue biopsies were requested.

Patients eligible had an advanced/metastatic NSCLC with no documented targetable alterations (EGFR, ROS1, MET exon 14 skipping mutation or ALK translocation) and received the tri-therapy associating avelumab, axitinib and palbociclib.

Dr. Benjamin Solomon talks about the preliminary results of SPRING trial at WIN 2019

June 23, 2019

https://youtu.be/G9JFRvflZ7Y

FDA Okays WIN Consortium Trial to Test Three-Drug NSCLC Combo; Validate SIMS Algorithm

- Genomeweb, August 11, 2017

Download pdf

SPRING 01 Trial: Patient Testimonial

November 15, 2018
https://www.youtube.com/watch?v=0le9amoRE9Q

SPRING Clinical trial - Avera Patient shares experience

September 24, 2018
https://youtu.be/oKJI_7p3IY0

Launch of WIN SPRING Clinical Trial Press Conference at Avera Cancer Institute, Sioux Falls, USA

January 24, 2018
https://www.youtube.com/watch?v=HrnCQ0rMXY8