Rui Manuel Reis has been involved in Cancer Research since 1996, at IPATIMUP/Porto (supervision of Prof. Sobrinho-Simões), working on thyroid cancer genetics. In 1997 GABBA fellow (Porto University) and started in 1998 the PhD at IARC/Lyon on molecular pathology of brain tumours (supervision of Prof. Paul Kleihues / Hiroko Ohgaki / Jose M Lopes). In 2002, post-doc at the VUMC/Amsterdam and IPATIMUP (co-supervision of Prof. Gerrit Meijer and Prof. Fátima Carneiro), on chromosomal aberrations of gastric tumours. In 2003, appointed Assistant Professor, and Associate Professor in 2021
of Human Genetics at the Medical Faculty, Minho University, Braga, Portugal, and Group Leader of Oncobiology. In 2010, at Barretos Cancer Hospital/Brazil, coordinating the Molecular Oncology Research Center and Molecular Diagnostic Laboratory, in 2015 appointed Scientific Director, and in 2018 to 2021 appointed Executive Director of Research and Teaching Institute. In 2021 was appointed Extraordinary Professor, at Pan African Cancer Research Institute, University of Pretoria, South Africa.

Expertise is in cancer biomarkers across distinct tumour types, and applying different methodologies, from SNP, gene mutations, copy number aberrations to gene expression alterations. Experience in international collaborations: COST - Molecular cytogenetics of solid tumours; Marie Curie Conferences -Genome Architecture in Relation to Disease; SIOP, Brain Tumour Committee; IMMENSE consortium; member and local coordinator of NCI-LACRN; Steering Committee of ICGC; Steering Committee of WIN; member and local coordinator of Mutograph (CRUK Grand Challenge).