SPRING Phase I trial results published: A WIN Consortium phase I study exploring avelumab, palbociclib, and axitinib in advanced non-small cell lung cancer
- Cancer Medicine, March 20, 2022
SPRING 01 Trial
SPRING 01 explored the safety and efficacy of the combination of a modulator of immune check point (avelumab), and two small molecule tyrosine kinase inhibitors (TKI) (axitinib and palbociclib).
During the Phase I, the tri-therapy was tested at different doses following a specific dose-escalation scheme in order to establish the safety and identify the recommended dose for the Phase II. The Phase II confirmed the safety and assessed the clinical utility of the tri-therapy approach in the treatment of advanced/metastatic NSCLC.
The study explored the clinical utility of the Simplified Interventional Mapping System (SIMS), a new tool/algorithm enabling matching of NSCLC patients with combination therapies. For this purpose tumor/metastasis and matched normal tissue biopsies were requested.
Patients eligible had an advanced/metastatic NSCLC with no documented targetable alterations (EGFR, ROS1, MET exon 14 skipping mutation or ALK translocation) and received the tri-therapy associating avelumab, axitinib and palbociclib.
Dr. Benjamin Solomon talks about the preliminary results of SPRING trial at WIN 2019
June 23, 2019
FDA Okays WIN Consortium Trial to Test Three-Drug NSCLC Combo; Validate SIMS Algorithm
- Genomeweb, August 11, 2017
SPRING 01 Trial: Patient Testimonial
November 15, 2018
Launch of WIN SPRING Clinical Trial Press Conference at Avera Cancer Institute, Sioux Falls, USA
January 24, 2018
Avera To Enrol First Patients in Landmark Lung Cancer Tri-Therapy Clinical Trial
- CNBC Global Newswire, January 19, 2018
When my son died of cancer I decided to wage war on the disease myself
- Independent, November 9, 2017
Simplified Interventional Mapping System (SIMS)
- Oncotarget, April 3, 2015