Dr. Razelle Kurzrock, Chief Medical Officer, WIN Consortium
“We are proud to partner with JIPO to help bring the latest knowledge about innovative therapies to patients suffering from malignancies.” Dr. Razelle Kurzrock, Chief Medical Officer, WIN Consortium

WINning together

WIN was formed on the premise that we can accomplish more together than each organization can achieve working alone. We aim to improve cancer patients’ survival and quality of life. View WIN's history and unique attributes:

WIN represents a global collaboration of cancer centers, life science and biotech organizations, pharmaceutical and technology companies and not-for-profit organizations.
The Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine was initiated in 2010 with leadership from leading cancer centers worldwide. WIN is a non-profit, non-governmental organization headquartered in Paris.

WIN was created to accelerate the pace and reduce the cost of translating novel cancer treatments to the bedside by developing and applying, through worldwide clinical trials and research projects, the most promising advances in genomic-based cancer research. WIN aims to initiate research projects each year in a global consortium guided by an independent scientific advisory board.

WIN now includes 34 institutional members. These stakeholders have come together from all parts of the world to address the challenge of increasing the efficacy of cancer diagnostics and therapeutics by understanding the genetics and biology of each individual’s tumor and accounting for genetic differences across diverse populations—from North and South America, Europe, Asia, and the Middle East.

Our goal is to significantly improve outcomes for patients around the globe. We aim to increase the number of patients worldwide that have access to innovative, global clinical trials in the area of genomic-based cancer therapeutics. Global diversity and inclusion of all stakeholders is WIN’s most important and differentiating asset.
WIN is comprised of organizations representing all stakeholders in personalized cancer medicine.
WIN enables cross-sector collaborations designed to accelerate the speed and efficacy with which breakthroughs in personalized cancer medicine can be realized and brought to patients worldwide.

Our members include leading academic, pharmaceutical, life science, not-for-profit, health, patient advocacy and IT organizations.
Our members include 26 leading academic centers representing 18 countries and four continents, enabling coordinated studies with a global patient population.
The response to a genetically-targeted therapy can vary due to differences in ethnicity and environment. WIN's global studies are designed to identify and account for this variability, enhancing the speed and efficacy with which novel discoveries can be made and brought to patients around the world.

WIN prioritizes cross-sector interaction designed to enhance learning across and between continents and healthcare sectors.
WIN Symposia, held annually, brings together hundreds of leaders representing all stakeholders from around the world in a forum designed to promote the exchange of ideas and information.

Clinical trials, projects and publications

WIN members collaboratively design and carry out global studies designed to achieve breakthroughs for patients worldwide. Our distinguished Scientific Advisory Board oversees WIN studies. Current trials include:

“Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival”
WIN's article “Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival” published by NPJ Precision Oncology, a Nature Research journal.
SPRING 01 (Survival Prolongation by Rationale Innovative Genomics) proof of concept trial is the first trial exploring the tri-therapy strategy in first line of advanced/metastatic non-small cell lung cancer (NSCLC), following the historical success of this approach in AIDS and tuberculosis for which only tri-therapy demonstrated long term efficacy.
The WIN SPRING trial will be conducted in the USA, France, Spain, Luxembourg and Israel in the following cancer centers: University of California - San Diego's Moores Cancer Center, Avera Cancer Institute (Sioux Falls, Arizona), Institut Curie (Paris), Centre Léon Bérard (Lyon), Hôpital Paris Saint-Joseph (Paris), Vall d'Hebron Institute of Oncology (Barcelona), Centre Hospitalier de Luxembourg (Luxembourg), and Chaim Sheba Medical Center (Israel).

The trial is sponsored by the WIN Consortium and funded by ARC Fondation for cancer research (France). The drugs are donated by Pfizer Inc.
Published in Nature Medicine, results of WINTHER, the first study pioneered by the WIN Consortium.
Published in Nature Medicine, results of WINTHER, the first study pioneered by the WIN Consortium.

Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial - shows that RNA profiling together with DNA testing matches more patients with advanced cancer to personalized therapies than DNA profiling for tumor mutations alone.

WIN is currently planning innovative global clinical trials that represent the next generation of studies focused on lung cancer.
European funded trials WINTHER EU FP7 funded and CHEMORES EU FP6 funded established foundations for WIN future global strategy for lung cancer currently under development.

The concept underlying the new strategy is developed in the following publications:

People leadership

WIN leaders are selected for their contributions and commitment to making effective, personalized cancer medicine a reality for patients around the world. They guide WIN's strategic, operational, and scientific direction.

Organization Photo


The WIN Consortium is organized in the following groups who collectively work together to achieve WIN's common goals

Richard L. Schilsky Photo
Chairman, WIN Consortium
Richard L. Schilsky

Chairman, WIN Consortium; Professor Emeritus, University of Chicago; past President and former Executive Vice President & Chief Medical Officer (ASCO) (USA)

Josep Tabernero Photo
Vice Chairman, WIN Consortium; Chair, WIN Scientific Advisory Board
Josep Tabernero

Vice Chairman, WIN Consortium; Head, Medical Oncology Department, Vall d'Hebron University Hospital (HUVH); Director, Vall d'Hebron Institute of Oncology, VHIO (Spain)

Razelle Kurzrock Photo
Chief Medical Officer, WIN Consortium
Razelle Kurzrock

Chief Medical Officer, WIN Consortium

Vladimir Lazar Photo
Chief Scientific and Operating Officer, WIN Consortium
Vladimir Lazar

Chief Scientific and Operating Officer, WIN Consortium

Catherine Bresson Photo
Director, Operational Team, WIN Consortium
Catherine Bresson

Director, Operational Team, WIN Consortium

Our members

WIN members include 34 leading organizations representing all stakeholders in personalized cancer medicine covering 18 countries and 4 continents. Our shared vision is delivering the promise of effective, personalized cancer medicine to patients worldwide.

WIN Symposia

WIN Symposia, held annually, gathers leaders representing a breadth of stakeholders from around the world to learn, share, and collaborate. Visit http://www.winsymposium.org for registration and additional information.

WIN 2022 Symposium logotype

WIN 2022 Symposium

March 14, 2022 - March 15, 2022


Program for WIN Symposium 2022 dedicated to ‘Integrating Genomics and Transcriptomics to reshape Precision Oncology: a WINning Strategy’ on March 14-15, 2022, Barcelona, Spain.

View the program and speaker profiles on our dedicated symposium website https://www.winsymposium.org!

WIN 2019 Symposium logotype

WIN 2019 Symposium

June 23, 2019 - June 24, 2019

The 11th edition of the WIN Symposia ‘WINnovation and Global Deployment of Precision Oncology’ took place in Paris, France on 23-24 June 2019.

Highlights and further information on the event, WIN 2019 can be found on our dedicated website at https://www.winsymposium.org/

WIN 2018 Symposium logotype

WIN 2018 Symposium

June 25, 2018 - June 26, 2018

The 10th year Anniversary edition of the WIN Symposia took place at the WIN Symposium 2018 in Paris, France on 25-26 June 2018.
The WIN Symposium Organizing Committee had chosen “Global Implementation of Precision Oncology: WINning the War against Cancer” as the theme for this celebratory event.

What people are saying

What people are saying
"WIN is an unique, global, translational clinical research organization with a bold vision to bring cutting edge science and technology to the cure of cancer worldwide. It is a privilege to help guide the organization as Chairman." Richard L. Schilsky, WIN Chairman
What people are saying
"Achieving much needed major clinical breakthroughs in cancer treatment requires bold thinking and action, a can do attitude and winning spirit, and close collaboration of stakeholders and contributors with diverse background and expertise. All this is epitomized by WIN." Vladimir Lazar, Chief Scientific and Operating Officer

JIPO and WIN Join Forces to Promote Immunotherapy and Precision Oncology in 2022
January 4, 2022 - The Journal of Immunotherapy and Precision Oncology (jipoonline.og) and WIN Consortium (winconsortium.org) are proud to announce a strategic partnership for 2022.

Aung Naing, MD, Editor-in-Chief of JIPO says, "We at JIPO are excited about our collaboration with WIN. Our shared vision is to advance clinical practice of immunotherapy and precision oncology that transforms patient care. JIPO is a peer-reviewed, open access journal with a fair and efficient double-blinded review process. Our mission is to disseminate accurate scientific knowledge, including both positive and negative studies, related to translational science and clinical medicine.” Naing further elaborates, "Our editorial board comprises renowned physicians and physician-scientists from diverse backgrounds and from different parts of the world. Our collaboration with WIN will enable us to realize our shared vision."

Razelle Kurzrock, MD, Chief Medical Officer of WIN says, “JIPO is positioned to have a high impact on the entire field of immunotherapy and precision oncology. The Worldwide Innovative Network (WIN) for precision medicine has goals well aligned with JIPO, considering its track record, including a multinational precision medicine that was the first to include transcriptomics as well as genomics in order to successfully match cancer patients with drugs. We are proud to partner with JIPO to help bring the latest knowledge about innovative therapies to patients suffering from malignancies."

JIPO and WIN will cross-promote both organization’s activities throughout the year, including the WIN 2022 Symposium in Barcelona, Spain, March 14-15, 2022. Abstracts selected for presentation at the WIN meeting will be published in JIPO as a Conference Proceeding.

JIPO Editorial Fellow, Dr. Khalid Jazieh, will be interviewing members of WIN Leadership to highlight the collaboration and upcoming activities. Drs. Razelle Kurzrock, Vladimir Lazar, and Richard L. Schilsky will be interviewed. These interviews will be published on the JIPO YouTube channel in the coming weeks.

Dr. Vladimir Lazar, Chief Scientific and Operating Officer of WIN, has been appointed to the JIPO Editorial Board to represent WIN Leadership. Dr. Lazar plans to contribute an editorial to the Journal in 2022. Dr. Kurzrock has published four articles in JIPO in 2019 and 2020 (complete list here).

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WIN SPRING 2021 Newsletter
Take a look at the latest developments in the WIN Consortium

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npj Precision Oncology Publication of "Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival”
NPJ Precision Oncology, a Nature Research journal
Apr 28, 2021

The expanding targeted therapy landscape requires combinatorial biomarkers for patient stratification and treatment selection. This requires simultaneous exploration of multiple genes of relevant networks to account for the complexity of mechanisms that govern drug sensitivity and predict clinical outcomes. We present the algorithm, Digital Display Precision Predictor (DDPP), aiming to identify transcriptomic predictors of treatment outcome. For example, 17 and 13 key genes were derived from the literature by their association with MTOR and angiogenesis pathways, respectively, and their expression in tumor versus normal tissues was associated with the progression-free survival (PFS) of patients treated with everolimus or axitinib (respectively) using DDPP. A specific eight-gene set best correlated with PFS in six patients treated with everolimus: AKT2, TSC1, FKB-12, TSC2, RPTOR, RHEB, PIK3CA, and PIK3CB (r = 0.99, p = 5.67E−05). A two-gene set best correlated with PFS in five patients treated with axitinib: KIT and KITLG (r = 0.99, p = 4.68E−04). Leave-one-out experiments demonstrated significant concordance between observed and DDPP predicted PFS (r = 0.9, p = 0.015) for patients treated with everolimus. Notwithstanding the small cohort and pending further prospective validation, the prototype of DDPP offers the potential to transform patients’ treatment selection with a tumor- and treatment-agnostic predictor of outcomes (duration of PFS).

npj Precision Oncology (2021)5:33;

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WIN Press Release
VILLEJUIF, FRANCE, April 30, 2021

The Worldwide Innovative Network in personalized cancer medicine consortium - WIN Consortium announces the publication of the Digital Display Precision Predictor: the
prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival for cancer patients in NPJ Precision Oncology (10.1038/s41698- 021-00171-6).

Precision oncology has led to approved, molecularly specific, biomarker-defined indications for targeted therapies. With the number of validated drug targets increasing, testing each patient’s tumor for all markers related to all possible targeted therapies becomes infeasible due to limited amount of tissue usually obtained by biopsies. In addition, the current companion diagnostic
approach used for most targeted therapies provides limited treatment options, with a binary "yes/no" expected response to a drug and no recommendation for which treatment, among a
range of possible options, is likely to be the best option for a particular patient.

The Digital Display Precision Predictor (DDPP), is a biomarker strategy and tool able to predict the duration of progression-free survival (PFS) for multiple targeted treatments for patients with advanced/metastatic cancers, based on the comprehensive investigation of the whole
transcriptome (the gene expression profile of the tumor compared to that of normal tissue).
DDPP is based on: 1) the exploration of the whole transcriptome (20,000 genes) providing insight about the status of activation of almost all drug targets in the context of the network of genes or pathways that drive tumor progression; 2) the data can be obtained from a single assessment requiring very small amounts of tumor and analogous normal tissues; and 3) the prediction of the duration of the time until tumor progression (PFS) under a specific therapeutic regimen.

"One of the main challenges of finding new biomarkers is that they are built in a relatively small number of patients treated with the same drug (from the WINTHER trial), for whom both molecular profiles (from tumor and analogous normal tissues) and PFS data were available," said Dr. Josep Tabernero, Vice-Chairman and Chairman of Scientific Advisory Board of WIN, Director, Vall d'Hebron Institute of Oncology, VHIO (Spain) and past ESMO President (2018-2019).

"The DDPP is potentially a new global biomarker tool that can apply to any type of cancer drug used alone or in combination, agnostic of tumor type, and can lead, pending further prospective validation, to a new approach to optimal treatment selection for patients with cancer," concluded Dr. Richard L. Schilsky, Chairman of WIN.

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© 1995-2021 IPD Group, Inc. All Rights Reserved
NEW YORK – Researchers within the Worldwide Innovative Networking (WIN) Consortium are pushing ahead with research to try to show that a transcriptomic algorithm can more precisely predict the extent to which cancer patients might benefit from targeted treatments or immunotherapy compared to genomic biomarkers.
Apr 30, 2021 Turna Ray
NEW YORK (GenomeWeb)

NEW YORK – Researchers within the Worldwide Innovative Networking (WIN) Consortium are pushing ahead with research to try to show that a transcriptomic algorithm can more precisely predict the extent to which cancer patients might benefit from targeted treatments or immunotherapy compared to genomic biomarkers.

In a paper published in NPJ Precision Oncology this week, researchers co-led by Vladimir Lazar, WIN's chief scientific and operating officer, described the development of a prototype "digital display precision predictor," or DDPP, which after further prospective validation, could provide insights into not just whether patients might respond to certain treatments, which is what current companion tests assessing genomic biomarkers assess, but also estimate the extent of their outcomes on these drugs.

WIN is an effort that brings together physician-scientists from cancer centers, drugmakers, and technology companies around the world to advance precision cancer research. A few years ago, WIN researchers conducted one of the first trials, called WINTHER, that used transcriptomics to prospectively match patients to drugs. That study didn't reach its primary endpoint, but it showed that transcriptomics can match patients to drugs when DNA sequencing cannot. It also was instrumental in the development of the DDPP, which Lazar presented as a novel biomarker concept in precision oncology.

Currently, oncologists hoping to identify personalized treatment options for their patients typically test their tumors for specific genomic aberrations using a variety of methods including immunohistochemistry, fluorescence in situ hybridization, PCR, and next-generations sequencing. And while testing for overexpression of certain genes, such as HER2, is standard of care in some tumor types, such as breast and stomach cancers, currently, oncologists are not fully sequencing the RNA in tumor and normal cells to gain a comprehensive picture of how gene expression may be harnessed to direct cancer treatment.

When patients come to oncologists for the first time suspecting cancer, Lazar said, the top questions on their minds are: Do they have cancer? Is there a treatment? And will they die of their disease? In his view, current biomarker testing methods oncologists are using to identify treatment options for patients aren't very precise.

Although DNA biomarker testing can tell you whether or not a patient is likely to respond to treatment, using these tests it is impossible to gauge the extent of a patient's response. Two patients with the same EGFR mutation driving their lung cancers may both initially respond to an EGFR inhibitor, but one patient may experience recurrence much sooner than the other.

"The major difference between DDPP and currently used technologies is that [DDPP] doesn't say 'yes' or 'no' in terms of treatment response but predicts the duration of the progression-free survival," Lazar explained. For example, "We're not saying whether patients will or won't response to everolimus [Novartis' Afinitor], but we can predict whether or not they will progress on therapy after six months, 12 months, 24 months or more. This is totally different."

In fact, in the previously reported WINTHER trial, one patient treated with the mTOR inhibitor everolimus lived without cancer progression for more than five years, but had no genomic tumor alterations, for example, in the PI2K/AKT/mTOR pathway that might explain the exceptional response. In comparison, patients with much shorter progression-free survival with gastrointestinal tract neuroendocrine tumors did have mutations in this pathway but didn't respond all that well, likely due to co-occurring resistance alterations.

To address the shortcomings of DNA biomarkers to fully explain the differences in responses seen in WINTHER, Lazar and colleagues described in the NPJ Precision Oncology paper DDPP, a transcriptomics-based algorithm that can be attuned to any drug under consideration for a patient. They demonstrated this by creating a predictive algorithm for patients likely to benefit from everolimus using data from the WINTHER trial. To develop the algorithm, researchers first sifted through the literature and identified a list of genes associated with treatment response.

In the case of everolimus, the researchers identified 17 genes in the MTOR pathway that bind to everolimus. They then characterized the differential expression of each of these genes in the tumor and normal samples of six patients in the WINTHER trial who received everolimus and correlated this differential expression with their progression-free survival on the drug.

Lazar and colleagues ranked the individual genes in order of significance in terms of their association with progression-free survival and built a predictor by adding the genes one by one to the algorithm and assessing its ability to predict progression-free survival until adding genes no longer improved the DDPP's predictive abilities. The iteration of the predictor that performed optimally in being able to predict progression-free survival in the six WINTHER patients included eight genes: AKT2, TSC1, FKB-12, TSC2, RPTOR, RHEB, PIK3CA, and PIK3CB.

"The higher the relative expression of these key genes in tumor tissue, the longer the progression-free survival is under treatment with everolimus," Lazar's team wrote in the paper.

To further test their approach, Lazar and colleagues ran another analysis where they developed predictive algorithms using five out of the six patients who received everolimus in WINTHER, and then tested the algorithms' ability to predict progression-free survival in the patient left out. Each time there was a significant concordance between the predicted and real progression-free survival of the patients left out. However, every iteration of the predictor included different subsets of genes, which suggested to the authors that when a small number of patients is used to generate the DDPP, it may be unstable.

Lazar and colleagues did this same experiment, generating a DDPP and evaluating its ability to predict progression-free survival in patients who received the tyrosine kinase inhibitor axitinib (Pfizer's Inlyta), the MEK inhibitor trametinib (Novartis' Mekinist), the EGFR inhibitor afatinib (Boehringer Ingelheim's Gilotrif), FGFR inhibitors, and immunotherapy, and reported similar findings.

Notably, since only a minority of patients experience enduring benefit with checkpoint inhibitors, there is significant interest in strategies to predict response with more precision than available biomarkers, such as PD-L1 expression and tumor mutation burden. In this study, Lazar developed a six-gene DDPP using data from three patients who received various PD-1 inhibitors in WINTHER and painted a tantalizing picture of the insights that can be gleaned using a transcriptomics algorithm.

They used the six-gene DDPP "in silico" to model the progression-free survival that could have been experienced by 82 patients in WINTHER if they had received a PD-1 inhibitor. The algorithm predicted that nearly 60 percent of patients would have progression-free survival of six months or less on immunotherapy, with the majority living less than three months without progression. Twenty-five patients, on the other hand, would live longer than that without progression, according to DDPP predictions, and 20 percent within this group would be progression free for more than two years.

The ability of Lazar's team to generate predictors for specific drugs was limited since only a few patients received the same treatment within WINTHER. Based on these experiments, however, the researchers showed that a DDPP predictor can be developed using data from as few as three patients. However, using statistical modeling they also showed that the DDPP starts to "become very robust" once you exceed 10 patients, Lazar said.

While promising, he acknowledged that this paper is only an initial demonstration of the DDPP concept and that it will need to be prospectively validated in a larger cohort of patients. His group has already started validating the DDPP and so far has data on 20 patients, which shows that the predictor becomes more precise and stabilizes with more patients. The group is in discussions about publishing this data.

In the current precision oncology paradigm, commercializing such a predictor may have its challenges, since the algorithm requires assessing transcriptomics in tumor and normal samples. "Since that's still not employed, that may be a limitation," Lazar acknowledged. "But a counterpoint is that there is a benefit to patients" in terms of being able to potentially identify with greater accuracy the treatments from which they will benefit most.

Another challenge with DDPP is that transcriptomics analysis is "problematic" and "not reliable" when done on paraffin-embedded tissue blocks, Lazar said, and should be done on fresh, frozen samples. The use of fresh, frozen tissue is also currently not standard practice when it comes to biomarker analysis.

"Today the standard of care in almost all the countries is to have paraffin biopsies and tumor-only [biomarker] analysis, usually via sequencing or IHC," Lazar said, noting that whenever introducing new concepts, one must weigh the relative benefit and risk to the patient.

In the WINTHER trial, his team previously showed that there is no added co-morbidity with additional sampling of normal tissue and patients are willing to provide it. At one time tumor tissue collection for biomarker analysis was also unusual in drug trials, Lazar reminded, and it took trials like BATTLE and others to incorporate the practice for it to take hold. Trials like WINTHER are trying to encourage the same when it comes to tumor/normal sampling, he said.

The willingness of risk-averse drugmakers to embrace a new concept like DDPP in the companion diagnostic realm is another consideration. Pharmaceutical companies are quite comfortable at this point relying on low-cost and widely available technologies like IHC for companion diagnostics that will identify the patients who will receive their drugs on a global scale. According to Lazar, the fact that DDPP can predict the duration of progression-free survival to their drugs, not just are they likely to respond, has caught the attention of drugmakers that have partnered with WIN and are familiar with its work in this regard.

Ultimately, he proposed that stakeholders in the field need to consider if the current biomarker methods in precision oncology are truly precise. "Or are there new possibilities?" Lazar asked. "It's interesting as an intellectual exercise to see a new prototype. Whether this will be implemented or not, only the future and further validation can say."

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