Dr. John Mendelsohn, Chairman, Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine
“Our mission is to rapidly translate personalized cancer medicine discoveries into standards of patient care worldwide.” Dr. John Mendelsohn, Chairman, Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine

WINning together

WIN was formed on the premise that we can accomplish more together than each organization can achieve working alone. We aim to improve cancer patients’ survival and quality of life. View WIN's history and unique attributes:

WIN represents a global collaboration of cancer centers, life science and biotech organizations, pharmaceutical and technology companies, health plans, and not-for-profit organizations.
The Worldwide Innovative Networking (WIN) Consortium in personalized cancer medicine was initiated in 2010 with leadership from leading cancer centers worldwide. WIN is a non-profit, non-governmental organization headquartered in Paris.

WIN was created to accelerate the pace and reduce the cost of translating novel cancer treatments to the bedside by developing and applying, through worldwide clinical trials and research projects, the most promising advances in genomic-based cancer research. WIN aims to initiate research projects each year in a global consortium guided by an independent scientific advisory board.

WIN now includes 35 institutional members. These stakeholders have come together from all parts of the world to address the challenge of increasing the efficacy of cancer diagnostics and therapeutics by understanding the genetics and biology of each individual’s tumor and accounting for genetic differences across diverse populations—from North and South America, Europe, Asia, and the Middle East.

Our goal is to significantly improve outcomes for patients around the globe. We aim to increase the number of patients worldwide that have access to innovative, global clinical trials in the area of genomic-based cancer therapeutics. Global diversity and inclusion of all stakeholders is WIN’s most important and differentiating asset.
WIN is comprised of organizations representing all stakeholders in personalized cancer medicine.
WIN enables cross-sector collaborations designed to accelerate the speed and efficacy with which breakthroughs in personalized cancer medicine can be realized and brought to patients worldwide.

Our members include leading academic, pharmaceutical, life science, not-for-profit, health IT, and healthpayer organizations.
Our members include 25 leading academic centers representing 17 countries and four continents, enabling coordinated studies with a global patient population.
The response to a genetically-targeted therapy can vary due to differences in ethnicity and environment. WIN's global studies are designed to identify and account for this variability, enhancing the speed and efficacy with which novel discoveries can be made and brought to patients around the world.

WIN's first trial, WINTHER, is currently being carried out through a collaboration between six academic centers in five countries, with key support from Europe (EUFP7), Fondation ARC, Pfizer and other pharma companies.
WIN prioritizes cross-sector interaction designed to enhance learning across and between continents and healthcare sectors.
WIN Symposia, held annually in Paris, bring together hundreds of leaders representing all stakeholders from around the world in a forum designed to promote the exchange of ideas and information.

Clinical trials and projects

WIN members collaboratively design and carry out global studies designed to achieve breakthroughs for patients worldwide. Our distinguished Scientific Advisory Board oversees WIN studies. Current trials include:

WINTHER, the WIN Consortium's first global personalized cancer medicine trial, is an ongoing global study carried out at multiple leading academic cancer centers around the world.
WINTHER aims to validate a breakthrough concept that would offer treatment guided by each patients biology for the vast majority of cancer patients.

With multiple cancer centers representing four countries - as well as partner biotech and pharma companies - WINTHER exemplifies WIN's commitment to innovative, collaborative studies that make effective, personalized medicine a reality for patients worldwide.
WIN is currently planning innovative global clinical trials that represent the next generation of studies focused on lung cancer.
European funded trials WINTHER EU FP7 funded and CHEMORES EU FP6 funded established foundations for WIN future global strategy for lung cancer currently under development.

The concept underlying the new strategy is developed in the following publications:
WIN provides a legal and fundraising framework that enables collective fundraising while protecting its members' intellectual property.
The WIN platform enables multiple organizations from different sectors to productively collaborate while providing for the protection of intellectual property. Each project or clinical trial has its own specific contract or funding mechanism.

People leadership

WIN leaders are selected for their contributions and commitment to making effective, personalized cancer medicine a reality for patients around the world. They guide WIN's strategic, operational, and scientific direction.

John Mendelsohn Photo
John Mendelsohn

Director, Khalifa Institute for Personalized Cancer Medicine and Past-President, the University of Texas MD Anderson Cancer Center (USA)

Richard L. Schilsky Photo
Chairman, WIN Scientific Advisory Board
Richard L. Schilsky

Chief Medical Officer, American Society of Clinical Oncology (ASCO); Chairman, WIN SAB

Razelle Kurzrock Photo
Chair, Clinical Trials Committee
Razelle Kurzrock

Chief, Division of Hematology & Oncology, Sr. Deputy Center Director for Clinical Science, University of California San Diego Moores Cancer Center (USA)

Vladimir Lazar Photo
Chief Scientific and Operating Officer
Vladimir Lazar

Chief Scientific and Operating Officer, WIN Consortium

Our members

WIN members include 37 leading organizations representing all stakeholders in personalized cancer medicine. Our shared vision is delivering the promise of effective, personalized cancer medicine to patients worldwide.

WIN Symposia

WIN Symposia, held annually in Paris, gather leaders representing a breadth of stakeholders from around the world to learn, share, and collaborate. Visit http://www.winsymposium.org for registration and additional information.

WIN 2017 Symposium logotype

WIN 2017 Symposium

June 26, 2017 - June 27, 2017

The WIN Consortium is pleased to announce that its 9th Annual Symposium ‘Expediting Global Innovation in Precision Cancer Medicine’ will be held in Paris, France, June 26-27, 2017. The overarching goal of our symposium is to share information to promote and accelerate cutting edge investigations and use of personalized, targeted cancer therapy.

Please visit our dedicated symposium website for more details: http://www.winsymposium.org

WIN 2016 Symposium logotype

WIN 2016 Symposium

June 27, 2016 - June 28, 2016

The WIN 2016 Symposium “Innovative Approaches to Improve Cancer Patient Outcomes”, June 27-28th was the eighth in a series of symposia dedicated to advancing personalized cancer medicine. It was a successful unique forum that brought leaders representing all stakeholders - academia, pharma, biotech / life sciences, regulatory, and health payer - together from around the globe.

WIN 2015 Symposium logotype

WIN 2015 Symposium

June 29, 2015 - June 30, 2015

The WIN 2015 Symposium, on the theme of “Novel Targets, Innovative Agents, Advanced Technologies: A WINNing Strategy?” featured a global array of many of the world’s leading experts in personalized cancer medicine - from academia, pharma, biotech, and governmental organizations.

What people are saying

Merck Becomes Member of the Worldwide Innovative Networking (WIN) in Personalized Cancer Medicine
June 15, 2017 06:00 AM Eastern Daylight Time

PARIS & DARMSTADT, Germany--(BUSINESS WIRE)--Worldwide Innovative Network in Personalized Cancer Medicine - WIN Consortium proudly announces today that Merck, which operates its biopharmaceutical business as EMD Serono in the U.S. and Canada, becomes a member of the WIN Consortium. WIN is a network of 40 academic institutions and industries across the globe, focusing on new generation biomarker-driven therapeutic clinical trials and biomarker discovery programs conducted worldwide, aiming to significantly impact the survival of cancer patients. Merck reinforces WIN’s pharmaceutical industry membership. WIN’s global collaborative research strategy will be presented at the WIN 2017 Symposium in Paris, France, on 26-27 June.

Merck’s strong corporate commitment to the development of drugs using a precision medicine approach, coupled with the company’s wide breadth of experience in the development of oncology therapeutics, its company’s goals and capabilities are strategically aligned with the mission of WIN.

"Bringing the latest advances in personalized cancer medicine to the patient requires collaboration and partnerships between multiple sectors of the health sciences community,” said Dr. John Mendelsohn, Chairman of WIN. “ Merck's strong commitment to the development of targeted cancer therapeutics and its breadth of expertise in oncology drug development will play a key role in accelerating the pace at which patients can benefit from advances in personalized cancer medicine. We are proud to have Merck and Pfizer Inc. as WIN's pharmaceutical partners and believe that this collaboration will benefit cancer patients worldwide." said Dr. Vladimir Lazar, Chief Scientific and Operating Officer of WIN.

The WIN Consortium is a global network of 40 leading organizations from the academic, pharmaceutical, biotechnology and patient advocacy sectors working to accelerate the pace and reduce the cost of translating novel cancer treatments to the bedside by developing and applying, through worldwide clinical trials, the most promising advances in genomic-based cancer research. WIN is a non-governmental, not-for-profit organization headquartered in Paris.

For further information, please visit www.winconsortium.org.

WIN Consortium
Catherine Bresson
Director Operational Team
Vladimir Lazar, Tel: + 33 66 109 15 22
Chief Scientific and Operating Officer
ASCO’s TAPUR Study Continues its Expansion of Sites, Participants, and Collaborators Thirty-six new locations—making TAPUR available at over 100 sites—new partnerships and expanded eligibility
June 3, 2017

CHICAGO – The American Society of Clinical Oncology’s (ASCO®) Targeted Agent and Profiling Utilization Registry (TAPUR) Study continues to expand and now has more than 300 participants enrolled on study drug, more than 100 sites, new partnerships, and a revised protocol to lower the age of eligibility.

"We are very pleased with the engagement from the cancer community in our TAPUR Study,” said ASCO Chief Medical Officer Richard L. Schilsky, MD, FACP, FASCO. “This growth in the study will help further our understanding of how these targeted therapies perform in patients with advanced cancer who have exhausted all other treatment options.”

Recently, eight new centers in 36 locations signed on to begin offering the TAPUR Study at their locations within the next few months:

Fox Chase Cancer Center – Pennsylvania, 1 site
Inova Schar Cancer Institute, Inova Health System – Virginia, 6 sites
Sutter Cancer Research Consortium – Northern California, 9 sites
The Angeles Clinic and Research Institute, a Cedars Sinai Affiliate – Southern California, 3 sites
The University of Texas MD Anderson Cancer Center – Texas, 5 sites
The University of Alabama at Birmingham Comprehensive Cancer Center – Alabama, 1 site
Sylvester Comprehensive Cancer Center, University of Miami – Florida, 7 sites
Winship Cancer Institute of Emory University – Georgia, 4 sites

This brings the total number of TAPUR sites to 101 in 20 states, a nearly threefold increase since the trial launched just over a year ago at 35 sites. At these sites, a total of 17 drugs yielding 15 different targeted therapy options (some drugs are used in combination) are available, which are provided by the seven pharmaceutical companies currently participating: AstraZeneca, Bayer, Bristol-Myers Squibb, Eli Lilly and Company, Genentech, Merck, and Pfizer.

In addition, the study protocol, with cooperation from stakeholders, has been revised to lower the age of eligibility into the trial. The revision decreases the enrollment age from 18 to 12 years to extend the opportunity for participation to adolescent patients with advanced cancer, where there is a defined adolescent dose for the study drugs. This protocol revision was recently approved by the Institutional Review Board and will be implemented soon.

In an effort to expand eligibility and facilitate logistics, the TAPUR team is engaging in several new collaborations with:

- Cure-One™ (formerly MED-C, The Molecular Evidence Development Consortium) “Patients Diagnosed with Advanced Malignancy or Myelodysplasia, Tested by Standardized Sequencing, and Treated by Physician-Determined Care Plan: A Cure-One Observational Registry (N1 Registry™)”: The registry includes next-generation sequencing data—a rapid DNA sequencing technology that can sequence an entire human genome in one day—alongside clinical outcomes. Through this collaboration, both ASCO and Cure-One will be in regular communication and will develop ways to identify and support patients who are eligible to participate in both initiatives. For example, a patient whose tumor undergoes genomic profiling through the N1 Registry™ may be a good candidate to participate in TAPUR and thus may have treatment options he or she could not otherwise receive.

- Caris Life Sciences® and Foundation Medicine, Inc: These two organizations are the first to receive the new “optimized for TAPUR reporting” designation, meaning that they provide a report organized to optimize identification of genomic alterations that match to TAPUR Study drugs. TAPUR sites ordering these tests will be able to easily identify relevant TAPUR variants on a specialized report for potential participants. Foundation Medicine will be offering its SmartTrials Report to select TAPUR Study sites to identify patients whose tests identify TAPUR-relevant results.

- Canadian Cancer Trials Group (CCTG) and WIN Consortium: Both CCTG and WIN Consortium have studies in development that are based on TAPUR, and ASCO aims to collaborate with them to share study results to accelerate learning. WIN Consortium—a global network of renowned academic cancer centers, pharmaceutical and diagnostic companies, and patient advocacy organizations spanning 16 countries and four continents—will offer an opportunity to expand data to more than a dozen countries outside of North America. WIN will be deploying WIN_TAPUR in the following countries: Brazil, China, Denmark, France, India, Israel, Japan, Jordan, Luxembourg, Russian Federation, Singapore, South Korea, and Spain.

ASCO’s global coordination also extends to the Netherlands, where the Society continues to work with the Netherlands Center for Personalized Cancer Treatment on its Drug Rediscovery Protocol (DRUP) trial, a protocol independently developed but very similar to TAPUR that allows international data sharing. The DRUP study is accruing in more than 18 sites, and 160 patients have been submitted.

ASCO also works with the Research Advocacy Network (RAN) on a sub-study that was developed to provide insights to help the oncology community understand how tumor genomic testing is being used by clinical oncologists and how to provide assistance with provider and patient education. The TAPUR sub-study also collects follow-up information from oncologists participating in the TAPUR Study to understand the changes in their confidence in and use of tumor genomic testing after being involved in TAPUR. Currently more than 100 physicians across 54 TAPUR sites are participating in the TAPUR sub-study.

The objective for the TAPUR Study is to evaluate molecularly targeted cancer drugs and collect data on clinical outcomes to learn about additional uses of these drugs outside of indications already approved by the Food and Drug Administration. ASCO is using Syapse Precision Medicine Platform to automate the matching of patients to treatments based on their genomic profiles, facilitate study workflows, and integrate clinical, genomic, treatment, and outcomes data. To help expand patient access, Syapse will be working towards automated patient matching in Syapse Oncology to identify patients who are eligible for TAPUR Study at partner health systems.

The TAPUR Study is registered on ClinicalTrials.gov (NCT 02693535), which includes a full list of inclusion/exclusion criteria and other information. Patients can find study information such as general eligibility criteria, participating clinical sites, and contact information for the study team at www.TAPUR.org. Researchers and practices interested in participating can visit the TAPUR study website for more information or contact the study team at: http://www.tapur.org/contact-us.

About ASCO:
Founded in 1964, the American Society of Clinical Oncology, Inc. (ASCO®) is committed to making a world of difference in cancer care. As the world’s leading organization of its kind, ASCO represents more than 40,000 oncology professionals who care for people living with cancer. Through research, education, and promotion of the highest-quality patient care, ASCO works to conquer cancer and create a world where cancer is prevented or cured, and every survivor is healthy. ASCO is supported by its affiliate organization, the Conquer Cancer Foundation. Learn more at www.ASCO.org, explore patient education resources at www.Cancer.Net, and follow us on Facebook, Twitter, LinkedIn, and YouTube.

WIN Consortium
Vladimir Lazar

Chief Operating and Scientific Officer
John Mendelsohn discusses WIN and WIN 2017 Symposium at AACR
Vladimir Lazar speaks about the forthcoming WIN 2017 Symposium at AACR